RAPHIN1

RAPHIN1

Biochem/physiol Actions

Raphin1 is an orally available, brain penetrant, potent and selective inhibitor of protein phosphatase 1 regulatory subunit 15B (PPP1R15B; R15B). It does not inhibit PP1c. Raphin1 transiently decreases protein synthesis in cells. It is efficacious in mouse model of Huntington’;s disease.

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Code Description Colour InChI key InChI Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576497 RAPHIN1 white to beige WLTSTDGGFCQWTK-YIXHJXPBSA-N 1S/C8H8Cl2N4/c9-6-3-1-2-5(7(6)10)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+ SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£486.11 (exc VAT) per EACH
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3576498 RAPHIN1 white to beige WLTSTDGGFCQWTK-YIXHJXPBSA-N 1S/C8H8Cl2N4/c9-6-3-1-2-5(7(6)10)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+ SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£119.93 (exc VAT) per EACH
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