PX 12, >=98% (HPLC), powder

PX 12, >=98% (HPLC), powder

Application

PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1? inhibitor to treat H2228 cells.

Biochem/physiol Actions

PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3573465 PX 12, >=98% (HPLC), powder off-white to tan 100 BPBPYQWMFCTCNG-UHFFFAOYSA-N 1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
£578.04 (exc VAT) per 25MG
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3573466 PX 12, >=98% (HPLC), powder off-white to tan 100 BPBPYQWMFCTCNG-UHFFFAOYSA-N 1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
£190.82 (exc VAT) per 5MG
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