PS10

PS10

Biochem/physiol Actions

PS10 is a potent and selective PDK (Pyruvate dehydrogenase kinase) inhibitor that improves glucose tolerance and lessens hepatic steatosis in diet-induced obese mice. PS10 binds to the ATP-binding pocket of PDKs.

2-[(2,4-dihydroxyphenyl) sulfonyl]isoindoline-4,6-diol (PS10) can be considered as a therapeutic method to preserve glucose and lipid homeostasis in obesity and type 2 diabetes (T2D). It can induce pyruvate dehydrogenase complex (PDC) activity in liver and kidney. It is also considered as an effective PDK inhibitor to treat diabetic cardiomyopathy. In the normal myocardium, PS10 helps to enhance fractional carbohydrate oxidation.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576287 PS10 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£565.50 (exc VAT) per 25MG
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3576288 PS10 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£140.68 (exc VAT) per 5MG
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