POSACONAZOLE

POSACONAZOLE

Application

Posaconazole has been used:in antifungal susceptibility testing of Aspergillus terreusas a lanosterol14?-demethylase (CYP51)-specific inhibitor to study its effects on membrane permeability in Candida albicans cellsto study its effects on promastigotes

Biochem/physiol Actions

Posaconazole is a highly potent broadspectrum antifungal agent against the yeast infection caused especially by Candida sp. It blocks the growth of fungi by inhibiting the enzymelanosterol14?-demethylase (CYP51). In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole exhibits antichagasic effects against different strains of Trypanosoma cruzi causing Chagas disease.

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Code Description Colour InChI key InChI Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576091 POSACONAZOLE white to beige RAGOYPUPXAKGKH-XAKZXMRKSA-N 1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33- SIGMA-ALDRICH
£695.04 (exc VAT) per 25MG
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3576092 POSACONAZOLE white to beige RAGOYPUPXAKGKH-XAKZXMRKSA-N 1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33- SIGMA-ALDRICH
£175.50 (exc VAT) per 5MG
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