POLOPPIN

POLOPPIN

Biochem/physiol Actions

Poloppin is a cell penetrant and potent inhibitor of mitotic Polo-like kinases (PLKs) that binds to the Polo-box domain (PBD) and prevents PLKs interaction with pSer/pThr phosphopeptide substrates. Poloppin induces mitotic arrest and apoptosis in cancer cells expressing mutant KRAS in 2D and organoid cultures. It also sensitizes mutant KRAS-expressing cancer cells to Crizotinib.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575933 POLOPPIN white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£504.21 (exc VAT) per 25MG
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3575934 POLOPPIN white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£94.02 (exc VAT) per 5MG
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