Plasmin from human plasma, lyophilized powder, >=2.0 units/mg protein

Descriptions

Application

A complex between plasmin and an inhibitor has been isolated in a study via affinity chromatography from urokinase-activated human plasma. It has also been used in a study to investigate activation of human epithelial sodium channel (ENaC) by plasmin and chymotrypsin.

Biochem/physiol Actions

Plasmin exhibits preferential cleavage at the carboxyl side of lysine and arginine residues with higher selectivity than trypsin. Converts polymerized fibrin into soluble products.pH Optimum: 8.5pH 7.5: ~40% of maximal activity, pH 9.5: ~50% of maximal activityTemperature Optimum: 37 °C with rapid inactivation at 56 °C

It is inhibited by ? 2-antiplasmin and its interaction with fibrin is blocked. It digests the N-terminal region of the cytoplasmic protein ?synuclein preventing its uptake by surrounding cells.

General description

Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes.

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing sodium phosphate, mannitol, and NaCl.

Unit Definition

One unit will produce one μmole of p-Nitroanilide from D-Val-Leu-Lys-p-Nitroanilide per minute at pH 7.5 at 37 °C.

Specifications

No detailed specifications are available for this product.

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Code	Description	Quality Level	Manufacturer	Storage Temp.	Impurities	Form	Price	Quantity
3579996	Plasmin from human plasma, lyophilized powder, >=2.0 units/mg protein	200	SIGMA-ALDRICH	−20°C	HIV, Hepatitis B and Hepatitis C, tested negative	lyophilized powder	Click Add to Quote for price and delivery	- +
3579997	Plasmin from human plasma, lyophilized powder, >=2.0 units/mg protein	200	SIGMA-ALDRICH	−20°C	HIV, Hepatitis B and Hepatitis C, tested negative	lyophilized powder	£266.00 (exc VAT) per 150UG	- +
3579998	Plasmin from human plasma, lyophilized powder, >=2.0 units/mg protein	200	SIGMA-ALDRICH	−20°C	HIV, Hepatitis B and Hepatitis C, tested negative	lyophilized powder	£644.64 (exc VAT) per 500UG	- +
3579999	Plasmin from human plasma, lyophilized powder, >=2.0 units/mg protein	200	SIGMA-ALDRICH	−20°C	HIV, Hepatitis B and Hepatitis C, tested negative	lyophilized powder	£893.00 (exc VAT) per EACH	- +