PIMECROLIMUS

PIMECROLIMUS

Biochem/physiol Actions

Pimecrolimus, also known as Picrolimus, is a macrolactam ascomycin derivative that acts as an immune suppressant. It binds with high affinity to macrophilin-12 (FKBP-12) and inhibits calcineurin, a calcium-dependent phosphatase. Pimecrolimus inhibits production of pro-inflammatory cytokines by T cells and mast cells and prevents the release of inflammatory cytokines and mediators from mast cells. It has been used clinically as a treatment for eczema.

Pimecrolimus is known for its anti-inflammatory and immunomodulatory properties and its low systemic immunosuppressive potential.

Packaging

10, 50 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3574906 PIMECROLIMUS white to beige 100 KASDHRXLYQOAKZ-XDSKOBMDSA-N 1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20- SIGMA-ALDRICH powder ≥97% (HPLC)
£150.43 (exc VAT) per 10MG
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3574907 PIMECROLIMUS white to beige 100 KASDHRXLYQOAKZ-XDSKOBMDSA-N 1S/C43H68ClNO11/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)45-16-12-11-13-32(45)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20- SIGMA-ALDRICH powder ≥97% (HPLC)
£601.71 (exc VAT) per 50MG
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