Picropodophyllotoxin, >=96% (HPLC), powder

Picropodophyllotoxin, >=96% (HPLC), powder

Biochem/physiol Actions

Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP can induce G2-M cell cycle arrest even in IGF-IR deficient cells. Hence, the role of PPP in IGF-IR-mediated anticancer functions is debatable.

Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor.

Features and Benefits

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

1, 5 mg in glass bottle

Preparation Note

Picropodophyllotoxin is soluble in DMSO at a concentration that is greater than 5 mg/ml.

Quality

May contain 2-3% ethanol (w/w)

No detailed specifications are available for this product.

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3576982 Picropodophyllotoxin, >=96% (HPLC), powder white 100 YJGVMLPVUAXIQN-HAEOHBJNSA-N 1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/ SIGMA-ALDRICH powder ≥96% (HPLC)
£171.32 (exc VAT) per 1MG
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3576983 Picropodophyllotoxin, >=96% (HPLC), powder white 100 YJGVMLPVUAXIQN-HAEOHBJNSA-N 1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/ SIGMA-ALDRICH powder ≥96% (HPLC)
£686.68 (exc VAT) per 5MG
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