PIAA

PIAA

Biochem/physiol Actions

PIAA is an inhibitor of TANK binding kinase 1 (TBK1) and IKB kinase epsilon (IKKε) that has been shown to promote regeneration of pancreatic β-cells. PIAA improved function and replication of mammalian β-cells including primary human β-cells and induced β-cell proliferation in streptozotocin-induced diabetic mice resulting in increased pancreas insulin content and improved glycemic control. PIAA exhibited an IC50 value of 400 nM for TBK1 and 1.07 µM for IKKε with minimum toxicity

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576500 PIAA white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear (warmed)
£483.32 (exc VAT) per 25MG
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3576501 PIAA white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear (warmed)
£119.93 (exc VAT) per 5MG
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