Phorbol 12-myristate 13-acetate, for molecular biology, >=99% (TLC)

Descriptions

Analysis Note

Stimulation of interleukin 2 production of Jurkat cells T-cell stimulation Protein kinase C (PKC) activator NF-κB Activator Promotion of cell growth Used in analytical studies of tumor promoters Molecular Biology grade

Application

PMA has been used:for the detection of intracellular cytokinesin CellROX oxidative stress assayfor Huh7 cell stimulation to investigate dipeptidyl peptidase 9 (DPP9) re-distributionas a positive control in B-cell receptor (BCR) stimulation of chronic lymphocytic leukaemia (CLL) cellsin the differentiation of monocytes (THP -1) into macrophages

Suitable for molecular biology studies as standard analytical studies of tumor promoters promotion of cell growth

Biochem/physiol Actions

Potent tumor promoter; activates protein kinase C in vivo and in vitro.

Potent tumor promoter; activates protein kinase C (PKC) in vivo and in vitro.

Caution

Photosensitive, protect from light.

Features and Benefits

General description

PMA (Phorbol 12-myristate 13-acetate) is an activator of protein kinase C (PKC) and a known tumor promoting agent. PMA also exhibits clastogenic (chromosome-breaking) activity.

Phorbol 12-myristate 13-acetate (PMA) can induce the activity of PLD1 (phospholipase D1) but not PLD2 (phospholipase D2).Through the protein kinase C (PKC) signaling pathway, PMA is a tumor promoter associated with:gene transcriptioncell growthcell differentiationprogrammed cell deathimmune pathwayreceptor desensitizationPhorbol 12-myristate 13-acetate is used to study:growth factorshormonescytokines-mediated regulation of cellular growth and differentiation

Specifications

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Code	Description	Quality Level	InChI key	InChI	Manufacturer	Storage Temp.	Solubility	Form	Assay	Price	Quantity
3582080	Phorbol 12-myristate 13-acetate, for molecular biology, >=99% (TLC)	200	PHEDXBVPIONUQT-RGYGYFBISA-N	1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,2	SIGMA-ALDRICH	−20°C	DMSO: soluble (DMSO solutions can be stored dark at −20Â °C for at least six months.); ethanol: soluble (Dissolve in water-miscible organi	film	≥99% (HPLC)	£1,032.11 (exc VAT) per 10MG	- +
3582081	Phorbol 12-myristate 13-acetate, for molecular biology, >=99% (TLC)	200	PHEDXBVPIONUQT-RGYGYFBISA-N	1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,2	SIGMA-ALDRICH	−20°C	DMSO: soluble (DMSO solutions can be stored dark at −20Â °C for at least six months.); ethanol: soluble (Dissolve in water-miscible organi	film	≥99% (HPLC)	£133.93 (exc VAT) per 1MG	- +
3582082	Phorbol 12-myristate 13-acetate, for molecular biology, >=99% (TLC)	200	PHEDXBVPIONUQT-RGYGYFBISA-N	1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,2	SIGMA-ALDRICH	−20°C	DMSO: soluble (DMSO solutions can be stored dark at −20Â °C for at least six months.); ethanol: soluble (Dissolve in water-miscible organi	film	≥99% (HPLC)	Click Add to Quote for price and delivery	- +
3582083	Phorbol 12-myristate 13-acetate, for molecular biology, >=99% (TLC)	200	PHEDXBVPIONUQT-RGYGYFBISA-N	1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,2	SIGMA-ALDRICH	−20°C	DMSO: soluble (DMSO solutions can be stored dark at −20Â °C for at least six months.); ethanol: soluble (Dissolve in water-miscible organi	film	≥99% (HPLC)	£328.71 (exc VAT) per EACH	- +