Phloretin, >=99%

Descriptions

Application

Phloretin has been used:to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-l-glucose (2-NBDLG) uptaketo incubate microvesicles in order to inhibit GLUT1 (glucose transporter 1)-mediated transport in radioactive ligand up-take assayas a component of KRH buffer to stop glucose uptake by trophoblast cells in vitro

Biochem/physiol Actions

Blocks L-type Ca²⁺ channels; activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers. Monocarboxylate transporter inhibitor.

Reacts with vic-dicarbonyl compounds such as glyoxal and methylglyoxal, preventing cytotoxic conjugation with biological macromolecules.

Phloretin is known to decrease interfacial dipole potential of lipid bilayer. Phloretin possess antitumor action by preventing protein kinase C (PKC) activity and stimulating programmed cell death. It is found to inhibit the transport functions of GLUTs (glucose transporter) and aquaporins.

General description

Major polyphenol found in apple; aglycone of phloridzin.

Phloretin a polar dye belongs to the class of dihydrochalcones.

Packaging

25, 100, 250 mg in poly bottle

Specifications

No detailed specifications are available for this product.

Downloads

There are no downloads for this product.

Code	Description	Quality Level	mp	InChI key	InChI	Manufacturer	Storage Temp.	Form	Assay	Price	Quantity
3577884	Phloretin, >=99%	200	~260 °C	VGEREEWJJVICBM-UHFFFAOYSA-N	1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2	SIGMA-ALDRICH	2-8°C	powder	≥99%	£207.54 (exc VAT) per 100MG	- +
3577885	Phloretin, >=99%	200	~260 °C	VGEREEWJJVICBM-UHFFFAOYSA-N	1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2	SIGMA-ALDRICH	2-8°C	powder	≥99%	£306.43 (exc VAT) per 250MG	- +
3577886	Phloretin, >=99%	200	~260 °C	VGEREEWJJVICBM-UHFFFAOYSA-N	1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2	SIGMA-ALDRICH	2-8°C	powder	≥99%	£90.81 (exc VAT) per 25MG	- +

Browse By

Featured Products

COBA Europe First-Step Tack Entrance Mat 0.45m x 1.17m White

Nalgene LDPE Economy Wash Bottles 250mL

FaraDRI Safety Trainers size 10

SLS Select Beaker PP 250mL

SLS Select Volumetric Flask 100mL Class A