PF-8380

PF-8380

Application

PF-8380 has been used in biological assays. It has also been used to estimate the role of intestinally-derived lysophosphatidic acid in dyslipidemia and atherosclerosis.

Biochem/physiol Actions

PF-8380 [6-(3-(piperazin-1-yl)propanoyl)benzo[d]oxazol-2(3H)-one] has the ability to change the resistant and invasive features of glioblastoma and helps to improve the response to radiation therapy.

PF-8380 is a potent orally bioavailable inhibitor of autotaxin (ATX), the enzyme that synthesize lysophosphatidic acid (LPA) from lysophosphatidyl choline, and is an emerging target for treatment of inflammatory conditions, including cancer, arthritis and multiple sclerosis. PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574107 PF-8380 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£547.39 (exc VAT) per 25MG
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3574108 PF-8380 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£143.46 (exc VAT) per 5MG
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