PF-2545920 HYDROCHLORIDE

PF-2545920 HYDROCHLORIDE

Biochem/physiol Actions

PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMP, and is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntington′s disease.

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Sold for research purposes under agreement from Pfizer Inc.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Solubility Form Assay Price Quantity
3573802 PF-2545920 HYDROCHLORIDE white to brown 100 SIGMA-ALDRICH DMSO: 20 mg/mL, clear
£536.25 (exc VAT) per 25MG
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3573803 PF-2545920 HYDROCHLORIDE white to brown 100 SIGMA-ALDRICH DMSO: 20 mg/mL, clear
£131.76 (exc VAT) per 5MG
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