PF-06928215

PF-06928215

Application

PF-06928215 has been used to study its inhibitory effects on cyclic GMP-AMP synthase (cGAS).

Biochem/physiol Actions

PF-06928215 is a high affinity (KD = 200 nM) active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 4.9 µM; in the presence of 1 mM ATP, 0.3 mM GTP, 100 nM 45-bp interferon-stimulatory dsDNA (ISD)). PF-06928215 displays no inhibitory potency against dsDNA-induced IFN-β expression in cellular cGAS assays, most likely due to limited cell-permeability and/or high levels of cellular ATP and GTP in the reporter cells employed.

Legal Information

Pfizer is a registered trademark of Pfizer, Inc.

Sold for research purposes under agreement from Pfizer Inc.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3573849 PF-06928215 white to beige SIGMA-ALDRICH room temp DMSO: 2 mg/mL, clear
£490.29 (exc VAT) per 25MG
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3573851 PF-06928215 white to beige SIGMA-ALDRICH room temp DMSO: 2 mg/mL, clear
£121.32 (exc VAT) per 5MG
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