PF-06807656

PF-06807656

Biochem/physiol Actions

PF-06807656 is a 3-sulfamoylbenzamide-based renal outer medullary potassium channel (ROMK, CCNJ1, Kir1.1) inhibitor (IC50 = 61 nM by whole cell patch clamp) that is insensitive to K80M or N171D pore mutation and exhibits high selectivity for human over rat species (IC50 against thallium sulfate/TlSO4-stimulated influx = 391 nM vs. >30 μM using human or rat ROMK1-expressing HEK293 cells; 82% vs. 0% inhibition by patch clamp using human or rat ROMK2-expressing HEK293 cells).

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Sold for research purposes under agreement from Pfizer Inc.

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3573870 PF-06807656 white to beige 100 SIGMA-ALDRICH 2-8°C
£366.32 (exc VAT) per EACH
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3573871 PF-06807656 white to beige 100 SIGMA-ALDRICH 2-8°C
£86.36 (exc VAT) per EACH
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