PF-06658607

PF-06658607

Application

PF-06658607 has been used to evaluate the proteome-wide selectivity of covalent kinase inhibitors.

Biochem/physiol Actions

PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-06658607 has been used as a probe for proteomic analysis to identify off-target binding substrates. The alkyne moiety allows for addition of an azide-based detection probe via copper-catalyzed click chemistry methods.

Legal Information

Pfizer is a registered trademark of Pfizer, Inc.

Sold for research purposes under agreement from Pfizer Inc.

Other Notes

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

5, 25 mg in glass bottle

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3573640 PF-06658607 white to beige 100 SIGMA-ALDRICH room temp
£533.46 (exc VAT) per 25MG
-
+
3573641 PF-06658607 white to beige 100 SIGMA-ALDRICH room temp
£151.82 (exc VAT) per 5MG
-
+