PF-06424439

PF-06424439

Application

PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2)inhibitor:to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cellsto study its effects on HeLa cellsto study its inhibitory effects on neutral lipid synthesis in HT-1080 cells

Biochem/physiol Actions

PF-06424439 functions in reducing the hepatic lipid levels in dyslipidemic rats.

PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).

Legal Information

Pfizer is a registered trademark of Pfizer, Inc.

Sold for research purposes under agreement from Pfizer Inc.

Other Notes

This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

5, 25 mg in glass bottle

No detailed specifications are available for this product.

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Code Description Colour InChI key InChI Manufacturer Form Assay Price Quantity
3573629 PF-06424439 white to light brown ZSTFDNQQOJUJFL-XFULWGLBSA-N 1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11, SIGMA-ALDRICH
£551.57 (exc VAT) per 25MG
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3573630 PF-06424439 white to light brown ZSTFDNQQOJUJFL-XFULWGLBSA-N 1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11, SIGMA-ALDRICH
£162.96 (exc VAT) per 5MG
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