PF-03814735

PF-03814735

Biochem/physiol Actions

PF-03814735 is a potent inhibitor of Aurora kinase A and B (IC50 = 5 and 0.8 nM, respectively). PF-03814735 inhibits proliferation of tumor cells in culture and in xenograft tumor models. The compound PF-03814735 blocks phosphorylation of Aurora B and Histone H3, and leads to the formation of polyploid cells in culture (HCT116 and MDA-MB-231).

Legal Information

Pfizer is a registered trademark of Pfizer, Inc.

Sold for research purposes under agreement from Pfizer Inc.

Other Notes

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3573611 PF-03814735 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£435.96 (exc VAT) per 25MG
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3573612 PF-03814735 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£153.21 (exc VAT) per 5MG
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