PEROSPIRONE HYDROCHLORIDE

PEROSPIRONE HYDROCHLORIDE

Biochem/physiol Actions

Perospirone (SM-9018) is a typical neuroleptic (antipsychotic) agent that displays high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki = 0.61, 1.4 and 2.9-1.8 nM, respectively), moderate affinity for alpha 1 and D1 receptors (Ki = 17 and 41 nM, respectively), while exhibiting much reduced affinity for alpha 2 (Ki = 408 nM) and little affinity toward muscarinic, opiate, glutamate, phencyclidine, benzodiazepine or GABAA receptors (Ki >1 µM). SM-9018 antagonizes both D2-dependent (e.g. methamphetamine-induced hyperactivity, apomorphine-induced stereotypy) and 5-HT2-mediated (e.g. tryptamine-induced clonic seizure) activities in vivo, while exhibiting very low cataleptogenic and central depressant activities commonly observed with two other neuroleptics, haloperidol and chlorpromazine.

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Code Description Colour InChI key InChI Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576155 PEROSPIRONE HYDROCHLORIDE white to beige HIZFAPMOZFYELI-GNXQHMNLSA-N 1S/C23H30N4O2S.ClH/c28-22-17-7-1-2-8-18(17)23(29)27(22)12-6-5-11-25-13-15-26(16-14-25)21-19-9-3-4-10-20(19)30-24-21;/h3-4,9-10,17-18H,1-2,5-8,11-16H2;1H/t17-,1 SIGMA-ALDRICH
£351.00 (exc VAT) per 25MG
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3576156 PEROSPIRONE HYDROCHLORIDE white to beige HIZFAPMOZFYELI-GNXQHMNLSA-N 1S/C23H30N4O2S.ClH/c28-22-17-7-1-2-8-18(17)23(29)27(22)12-6-5-11-25-13-15-26(16-14-25)21-19-9-3-4-10-20(19)30-24-21;/h3-4,9-10,17-18H,1-2,5-8,11-16H2;1H/t17-,1 SIGMA-ALDRICH
£108.36 (exc VAT) per 5MG
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