PEMETREXED DISODIUM HEPTAHYDRATE

PEMETREXED DISODIUM HEPTAHYDRATE

Application

Pemetrexed disodium heptahydrate has been used as a folate antimetabolite to study its effects on ovarian clear cell carcinoma cells. It has also been used as an antifolate to determine its effects on neuroblastoma cell lines.

Biochem/physiol Actions

Pemetrexed exhibits its activity against several tumors such as colorectal, breast, gastric, pancreatic, and cervical cancer. It acts as a substrate for multidrug resistance protein transporters.

Pemetrexed is antifolate cancer drug approved for treatment of variety of cancer including pleural mesothelioma and non-small cell lung cancer. Pemetrexed is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, three enzymes used in purine and pyrimidine synthesis.

Packaging

10, 50 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574980 PEMETREXED DISODIUM HEPTAHYDRATE white to beige 100 SIGMA-ALDRICH 2-8°C
£135.80 (exc VAT) per 10MG
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3574981 PEMETREXED DISODIUM HEPTAHYDRATE white to beige 100 SIGMA-ALDRICH 2-8°C
£550.18 (exc VAT) per 50MG
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