PALOMID 529

PALOMID 529

Biochem/physiol Actions

Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor, which is unique in that it causes the dissociation of both the TORC1 and TORC2 complexes and inhibits both Akt and mTOR signaling. Palomid 529 has been shown to inhibit tumor growth, angiogenesis, and vascular permeability. Palomid 529 (P529) inhibited glioblastoma growth, penetrating the blood brain barrier with little affinity for ATP-binding cassette (ABC) drug efflux transporters ABCB1 and ABCG2. Palomid 529 has also shown promise as a possible treatment for macular degeneration and keloid disease.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574124 PALOMID 529 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
£314.79 (exc VAT) per 25MG
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3574125 PALOMID 529 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
£86.08 (exc VAT) per 5MG
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