PAC-1, >=98% (HPLC), solid, solubility: <=2 mg/mL in deionized water

PAC-1, >=98% (HPLC), solid, solubility: <=2 mg/mL in deionized water

Biochem/physiol Actions

PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 µM and caspase 7= 4.5 µM. The IC50 for apoptosis induction = 0.92 µM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Procaspase-activating compound 1 (PAC-1) is an ortho-hydroxy N-acyl hydrazine compound. It is cytotoxic to a variety of cancer cells, such as lymphoma, leukaemia, breast carcinoma and glioblastoma. High doses of PAC-1 can promote neuroexcitation. It helps in the in vitro autoactivation of the proenzyme protease, which acts as a prototype for other protease activating compounds. PAC-1 dependant activation of procaspase-3 is associated with the chelation of zinc.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3573518 PAC-1, >=98% (HPLC), solid, solubility: <=2 mg/mL in deionized water white 100 YQNRVGJCPCNMKT-LFVJCYFKSA-N 1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16+ SIGMA-ALDRICH deionized water: &le;2 mg/mL, DMSO: &ge;10 mg/mL solid &ge;98% (HPLC)
£459.64 (exc VAT) per 25MG
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3573519 PAC-1, >=98% (HPLC), solid, solubility: <=2 mg/mL in deionized water white 100 YQNRVGJCPCNMKT-LFVJCYFKSA-N 1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,29H,1,7,12-15,17-18H2,(H,25,28)/b24-16+ SIGMA-ALDRICH deionized water: &le;2 mg/mL, DMSO: &ge;10 mg/mL solid &ge;98% (HPLC)
£125.78 (exc VAT) per 5MG
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