OPHIOBOLIN A

OPHIOBOLIN A

Biochem/physiol Actions

Ophiobolin A is a fungal metabolite, toxic to many crops and found to have antimicrobial and anticancer activity. Ophiobolin A is a calmodulin antagonist and inhibitor of big conductance Ca2+-activated K+ channel (BKCa) activity. Its anticancer activity may involve inhibition of multiple oncogenic signaling pathways including PI3K/mTOR, Ras/Raf/ERK and CDK/RB. One study suggested the possibility of pyrrolylation of lysine residues on its intracellular target protein(s) as a mechanism of action on various targets.

Other Notes

Light and air sensitive.

Packaging

1 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3574963 OPHIOBOLIN A white to beige 100 MWYYLZRWWNBROW-BDZRSQQBSA-N 1S/C25H36O4/c1-15(2)10-18-11-16(3)25(29-18)9-8-23(4)12-19-22(20(27)13-24(19,5)28)17(14-26)6-7-21(23)25/h6,10,14,16,18-19,21-22,28H,7-9,11-13H2,1-5H3/b17-6-/t16 SIGMA-ALDRICH powder ≥95% (HPLC)
£118.81 (exc VAT) per 100UG
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3574964 OPHIOBOLIN A white to beige 100 MWYYLZRWWNBROW-BDZRSQQBSA-N 1S/C25H36O4/c1-15(2)10-18-11-16(3)25(29-18)9-8-23(4)12-19-22(20(27)13-24(19,5)28)17(14-26)6-7-21(23)25/h6,10,14,16,18-19,21-22,28H,7-9,11-13H2,1-5H3/b17-6-/t16 SIGMA-ALDRICH powder ≥95% (HPLC)
£371.89 (exc VAT) per 1MG
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