OGG1 INHIBITOR O8

OGG1 INHIBITOR O8

Biochem/physiol Actions

OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.

General description

Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3575282 OGG1 INHIBITOR O8 white to beige 100 HSSHUDKWJRJKPV-UHFFFAOYSA-N 1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14) SIGMA-ALDRICH DMSO: 5 mg/mL, clear powder ≥98% (HPLC)
£502.82 (exc VAT) per 25MG
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3575283 OGG1 INHIBITOR O8 white to beige 100 HSSHUDKWJRJKPV-UHFFFAOYSA-N 1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14) SIGMA-ALDRICH DMSO: 5 mg/mL, clear powder ≥98% (HPLC)
£124.38 (exc VAT) per 5MG
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