OG-L002 HYDROCHLORIDE

OG-L002 HYDROCHLORIDE

Biochem/physiol Actions

OG-L002 is a recently developed inhibitor with IC50 of 20 nM at LSD1 and much lower activity at MAO-A and MAO-B (1.38 and 0.72 µM, respectively). OG-L002 exhibits potent anti-viral activity in vitro and in mouse models of HSV infection. Lysine specific demethylase 1 (LSD1) is a histone demethylase that removes methyl groups from lysine 4 or 9 of H3 histone tails. Inhibition of LSD1 leds to suppression of herpes simplex and herpes zoster viral infections and viral reactivation from latency. MAO inhibitors (pargyline, tranylcypromine) are known to inhibit LSD1, but with low potency and selectivity. OG-L002 is a more selective and potent tool for LSD1 inhibition.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574835 OG-L002 HYDROCHLORIDE , light yellow to dark orange 100 LPVCAMIPTMRRLZ-LIOBNPLQSA-N 1S/C15H15NO.ClH/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12;/h1-8,14-15,17H,9,16H2;1H/t14-,15+;/m1./s1 SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£656.04 (exc VAT) per 25MG
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3574836 OG-L002 HYDROCHLORIDE , light yellow to dark orange 100 LPVCAMIPTMRRLZ-LIOBNPLQSA-N 1S/C15H15NO.ClH/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12;/h1-8,14-15,17H,9,16H2;1H/t14-,15+;/m1./s1 SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£193.61 (exc VAT) per 5MG
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