OCTYL-(R)-2HG

OCTYL-(R)-2HG

Application

Octyl-(R)-2 hydroxyglutarate (HG) has been used as a membrane permeamble oncometabolite in gliblostoma cells to test its effects on NANOG transcription factor expression. It has also been used as a competitive inhibitor of the enzyme ?-ketoglutarate (?-KG)-dependent deoxygenase.

Biochem/physiol Actions

Octyl-(R)-2HG (Octyl-D-2HG) is a membrane-permeant precursor form of the oncometabolite D-2-hydroxyglutarate (D-2HG) produced by tumor cells due to mutations in the NADP+-dependent isocitrate dehydrogenase genes IDH1 and IDH2. D-2HG inhibits multiple A-ketoglutarate/A-KG-dependent dioxygenases by competing against A-KG binding. Cellular D-2HG delivery by Octyl-(R)-2HG treatment (1-50 mM) is shown to suppress demethylase activity (~148% H3K9me2 and ~310% H3K79me2 upregulation; 50 mM in U-87MG) as well as increase HIF-1A and decrease endostatin levels as a result of inhibiting A-KG-dependent dioxygenases prolyl hydroxylases (PHDs) and collagen prolyl-4-hydroxylase (C-P4H), respectively.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575950 OCTYL-(R)-2HG colorless SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£718.71 (exc VAT) per 25MG
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3575951 OCTYL-(R)-2HG colorless SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£178.29 (exc VAT) per 5MG
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