OB-1

OB-1

Biochem/physiol Actions

OB-1 is an inhibitor of the oligomerization of Stomatin-like protein-3 (STOML3), which is a modulator of the mechanosensitive ion channel Piezo2. STOML3 requires oligomerization for its role as an endogenous regulator of the sensitivity of mechanosensitive Piezo ion channels in sensory neurons. By inhibiting this activity, OB-1 has been shown to reduce touch-evoked pain behavior in two mouse models of neuropathic pain.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576493 OB-1 white to very dark brown SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£388.61 (exc VAT) per 25MG
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3576494 OB-1 white to very dark brown SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£119.93 (exc VAT) per 5MG
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