NG25 TRIHYDROCHLORIDE

NG25 TRIHYDROCHLORIDE

Application

NG25 trihydrochloride has been used as a transforming growth factor ? (TGF?)-activated kinase 1 inhibitor (TAK1) in human umbilical vein endothelial cells (HUVECs) and pulmonary artery smooth muscle cells.

Biochem/physiol Actions

NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

Other Notes

Light sensitive

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574760 NG25 TRIHYDROCHLORIDE white to beige 100 SMPGEBOIKULBCT-UHFFFAOYSA-N 1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-1
£604.50 (exc VAT) per 25MG
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3574761 NG25 TRIHYDROCHLORIDE white to beige 100 SMPGEBOIKULBCT-UHFFFAOYSA-N 1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-1
£224.25 (exc VAT) per 5MG
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