NEOSEPTIN-3

NEOSEPTIN-3

Biochem/physiol Actions

Neoseptin-3 stimulates the activity of mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (mTLR) independently of CD14 (cluster of differentiation 14). This activated mTLR4/ mTLR promotes canonical myeloid differentiation primary response gene 88 (MyD88) and toll-interleukin(IL) 1 receptor (TIR) domain-containing adaptor inducing interferon (IFN)-? (TRIF)-dependent signaling. In addition, neoseptin-3 also stimulates tumor necrosis factor ? (TNF-?), IL-6 and IFN? production in a dose-dependent manner.

Neoseptin-3 is a highly efficacious and specific agonist of the mouse TLR4 (mTLR4)/myeloid differentiation factor 2 (MD-2) complex. Neoseptin-3 binds to MD2, changes the conformation of MD-2 and facilitates active TLR4/MD-2 dimer formation. Neoseptin-3 exhibits no structural similarity to lipid A.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575266 NEOSEPTIN-3 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 15 mg/mL, clear powder ≥98% (HPLC)
£462.43 (exc VAT) per 25MG
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3575267 NEOSEPTIN-3 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 15 mg/mL, clear powder ≥98% (HPLC)
£138.73 (exc VAT) per 5MG
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