NCT-501

NCT-501

Biochem/physiol Actions

NCT-501 is a potent and selective inhibitor of Aldehyde dehydrogenase ALDH1A1, a dehydrogenase that has been found to be elevated in certain cancers and in cancer stem cells. NCT-501 had an IC50 value of 40 nM and was found to be 1000-fold selective for ALDH1A1 over other ALDH enzymes and other dehydrogenases. NCT-501 treatment of head and neck squamous-cell carcinoma (HNSCC) explants in combination with cisplatin resulted in a significant decrease in proliferating cells.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575804 NCT-501 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£575.25 (exc VAT) per 25MG
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3575805 NCT-501 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£151.82 (exc VAT) per 5MG
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