MSC1094308

MSC1094308

Biochem/physiol Actions

MSC1094308 is a reversible, non-ATP-competitive, type I AAA ATPase VPS4B-selective allosteric inhibitor (IC50 = 0.71 µM) with =10-fold reduced potency toward the type II AAA ATPase VCP/p97 and NSF (IC50 = 7.2 and >40 µM, respectively). MSC1094308 specifically inhibits p97-mediated Ub-GFP degradation without affecting proteasome-dependent ODD-luc degradation using a dual reporter HeLa cell line (10 µM) and exhibits comparable efficacy as DBeQ against 50 ng/mL TNFα-induced IκBα degradation in HeLa cells (10 µM).

MSC1094308 binding to drugable hotspot of p97 has the ability to block the D2 ATPase activity.

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576149 MSC1094308 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£540.43 (exc VAT) per 25MG
-
+
3576150 MSC1094308 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£134.27 (exc VAT) per 5MG
-
+