MS645

MS645

Biochem/physiol Actions

MS645 is a cell penetrant bivalent bromodomain (BRD) inhibitor that inhibits the tandem BD1/BD2 of BRD4. It potently represses BRD4 transcriptional activity in solid-tumor cells including TNBC. MS645 potently inhibits IL-6 expression MDA-MB-231 cells. MS645 exhibits sustained blockade of BRD4 by inhibition of BRD4 interactions with transcription enhancer/mediator proteins MED1 and YY1.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576475 MS645 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£653.25 (exc VAT) per 25MG
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3576476 MS645 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£206.14 (exc VAT) per 5MG
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