MPS1-IN-3

MPS1-IN-3

Application

Mps1-IN-3 has been used in 2D-proliferation and 3D-organotypic culture outgrowth assays.

Biochem/physiol Actions

Mps1 mediates phosphorylation of kinetochore scaffold 1.

Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1, also known as TTK), a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC50 value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC50 value of approximately 5 µM, and sensitized glioblastoma cells to vincristine in orthotopic mouse models.

General description

Monopolar spindle 1 (Mps1) protein contains a TPR (tetratricopeptide repeat) motif at its N-terminal and a C-terminal kinase domain.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574218 MPS1-IN-3 light yellow to dark yellow 100 OFRMASLPWOMYHN-UHFFFAOYSA-N 1S/C26H31N7O4S/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33/h4-9,14-16,18,34H,10-13
£619.77 (exc VAT) per 25MG
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3574219 MPS1-IN-3 light yellow to dark yellow 100 OFRMASLPWOMYHN-UHFFFAOYSA-N 1S/C26H31N7O4S/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33/h4-9,14-16,18,34H,10-13
£174.11 (exc VAT) per 5MG
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