MP-A08

MP-A08

Biochem/physiol Actions

MP-A08 is a highly selective ATP-competitive sphingosine kinase inhibitor that targets both SK1 and SK2. It is more selective and acts by different mechanisms than other SK inhibitors. MP-A0 targets the ATP-binding pocket, rather than the sphingosine binding pocket, with Ki values of 6.9 and 27 µM, respectively. Also, both SKI-II and PF-543 are thought to act in part by targeting sphingosine kinase for proteasomal degradation, which is not the case with MP-A08. MP-A08 was found to suppress the growth of human lung tumor xenografts in mice, both inducing apoptosis and inhibiting angiogenesis.

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576650 MP-A08 white to beige 100 SIGMA-ALDRICH 2-8°C
£390.00 (exc VAT) per EACH
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3576651 MP-A08 white to beige 100 SIGMA-ALDRICH 2-8°C
£119.93 (exc VAT) per EACH
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