MONOCLONAL IGD (EP173)

MONOCLONAL IGD (EP173)

General description

The monoclonal antibody against IgD reacts with immunoglobin D delta chains. In tonsil and lymph node, immunohistochemical staining for IgD immunoglobulin heavy chain is usually used to highlight the tonsil and nodal architecture since the IgD antibody stains mantle zone cells in secondary follicles and mantle cells in primary follicles.1 It has been reported that IgD can be detected in the surface/cytoplasm of neoplastic cells of common small B lymphoid cell lymphomas, such as small lymphocytic lymphoma, mantle cell lymphoma, marginal zone lymphoma (especially splenic marginal zone lymphoma), and follicular lymphoma.1-2 IgD expression in L & P cells of nodular lymphocyte predominant Hodkin lymphoma has been seen in subsets of cases (27% to 71.4%).1-3 The IgD positive L & P cells are usually located in the extrafollicular area with a relatively T-cell-rich background1,3 IgD expression is rarely seen in T-cell rich B-cell lymphoma. Studies have demonstrated that Reed-Sternberg cells of classic Hodgkin lymphoma were negative for IgD1,3 IgD multiple myeloma is a rare bone marrow plasma cell dyscrasia and can be identified by the IgD antibody, especially when a dry tap is encountered.4

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

IgD Positive Control Slides, Product No. 268S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide.

Preparation Note

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Quality

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Code Description Quality Level Manufacturer Further Info Storage Temp. Form Price Quantity
3572948 MONOCLONAL IGD (EP173) 100; 500 SIGMA-ALDRICH (For In Vitro Diagnostic Use in Select Regions (See Chart)) 2-8°C buffered aqueous solution
£212.91 (exc VAT) per EACH
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