MLS000389544, >=98% (HPLC)

MLS000389544, >=98% (HPLC)

Biochem/physiol Actions

MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2). It effectively block TR-mediated gene transcription. MLS000389544 is selective for TR over other NR family members. It appears to act by irreversible mechanisms and target cysteine residues in the coactivator binding pocket.

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574027 MLS000389544, >=98% (HPLC) white to beige 100 BTXTVUJWNPMQBT-UHFFFAOYSA-N 1S/C20H24N2O7S/c1-30(27,28)17-3-2-15(7-16(17)22(25)26)19(24)29-11-18(23)21-20-8-12-4-13(9-20)6-14(5-12)10-20/h2-3,7,12-14H,4-6,8-11H2,1H3,(H,21,23) SIGMA-ALDRICH H2O: ≥5 mg/mL (warmed) powder ≥98% (HPLC)
£544.61 (exc VAT) per 25MG
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3574028 MLS000389544, >=98% (HPLC) white to beige 100 BTXTVUJWNPMQBT-UHFFFAOYSA-N 1S/C20H24N2O7S/c1-30(27,28)17-3-2-15(7-16(17)22(25)26)19(24)29-11-18(23)21-20-8-12-4-13(9-20)6-14(5-12)10-20/h2-3,7,12-14H,4-6,8-11H2,1H3,(H,21,23) SIGMA-ALDRICH H2O: ≥5 mg/mL (warmed) powder ≥98% (HPLC)
£182.46 (exc VAT) per 5MG
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