ML221

ML221

Biochem/physiol Actions

ML221 is capable of suppressing the cultured-endothelial cell proliferation. In oxygen-induced retinopathy (OIR) mice model, ML221 can block the pathological angiogenesis and increase the recovery of normal vessels into the ischemic regions in the retina. It can also inhibit the formation of neovascular tufts.

ML221 is an antagonist of the apelin receptor (also known as APJ). ML221 blocks Apelin-13 mediated receptor activation (recruitment of β-arrestin) with an IC50 of 1.75 µM.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574246 ML221 white to beige 100 SIGMA-ALDRICH 2-8°C
£537.64 (exc VAT) per 25MG
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3574247 ML221 white to beige 100 SIGMA-ALDRICH 2-8°C
£136.50 (exc VAT) per 5MG
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