ML162

ML162

Biochem/physiol Actions

ML162 is a small molecule that induces ferroptosis via covalent inhibition of cellular phospholipid glutathione peroxidase (GPX-4; GPX4; GSHPx-4; PHGPx; snGPx; snPHGPx). Synthetic lethality studies in cancer cultures identify contributing factors such as HRas(G12V) expression and fumarate hydratase (FH) deletion to ML162 sensitivity (IC50 = 25 nM & 35 nM, respectively, in BJeLR-HRas(G12V) & UOK262-FH-/- cultures).

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576495 ML162 white to very dark brown SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£486.11 (exc VAT) per 25MG
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3576496 ML162 white to very dark brown SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£119.93 (exc VAT) per 5MG
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