ML 141, >=98% (HPLC)

ML 141, >=98% (HPLC)

Application

ML 141 has been used:to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cellsas inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nucleias actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondriaas a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells

Biochem/physiol Actions

ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.

Features and Benefits

This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574061 ML 141, >=98% (HPLC) white to beige 100 QBNZBMVRFYREHK-UHFFFAOYSA-N 1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27) SIGMA-ALDRICH DMSO: 5 mg/mL (warmed, clear solution) powder ≥98% (HPLC)
£603.11 (exc VAT) per 25MG
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3574062 ML 141, >=98% (HPLC) white to beige 100 QBNZBMVRFYREHK-UHFFFAOYSA-N 1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27) SIGMA-ALDRICH DMSO: 5 mg/mL (warmed, clear solution) powder ≥98% (HPLC)
£150.43 (exc VAT) per 5MG
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