MK6-83

MK6-83

Biochem/physiol Actions

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.

MK6-83is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575006 MK6-83 white to brown 100 SIGMA-ALDRICH 2-8°C
£426.21 (exc VAT) per 25MG
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3575007 MK6-83 white to brown 100 SIGMA-ALDRICH 2-8°C
£115.47 (exc VAT) per 5MG
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