MIND4-17

MIND4-17

Biochem/physiol Actions

MIND4-17 is a potent NRF2 (nuclear factor erythroid 2-related factor 2) activator that covalently modifies a critical stress-sensor cysteine (C151) in the BTB domain of the E3 ligase substrate adaptor protein Kelch-like ECH-associated protein 1 (KEAP1), the primary negative regulator of NRF2. MIND4-17 induces NRF2 activation responses in neuronal and non-neuronal cultures (effective conc. 0.1-10 µM) of human, mouse, and rat origins. In addition, MIND4-17 effectively reduces endotoxin-induced IL-6 release from WT as well as YAC128 HD mutant mice-derived primary microglia and astrocytes, however, NRF2 induction by MIND4-17 is shown to be compromised in human Huntington′s diseased (HD) relative to non-disesed neural stem cells due to suppressive influence of the expanded CAG repeat mutation on pathway activation.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575705 MIND4-17 white to brown SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear (warmed)
£391.39 (exc VAT) per 25MG
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3575706 MIND4-17 white to brown SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear (warmed)
£174.11 (exc VAT) per 5MG
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