Methotrexate, meets USP testing specifications

Methotrexate, meets USP testing specifications

Application

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

Biochem/physiol Actions

Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.

Packaging

25, 100, 500 mg in poly bottle

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Quality Level InChI key InChI Manufacturer Agency Storage Temp. Form Price Quantity
3591838 Methotrexate, meets USP testing specifications 200 FPJYMUQSRFJSEW-ZOWNYOTGSA-N 1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30 SIGMA-ALDRICH meets USP testing specifications, USP/NF −20°C powder
£510.07 (exc VAT) per 100MG
-
+
3591839 Methotrexate, meets USP testing specifications 200 FPJYMUQSRFJSEW-ZOWNYOTGSA-N 1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30 SIGMA-ALDRICH meets USP testing specifications, USP/NF −20°C powder
£171.79 (exc VAT) per 25MG
-
+
3591840 Methotrexate, meets USP testing specifications 200 FPJYMUQSRFJSEW-ZOWNYOTGSA-N 1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30 SIGMA-ALDRICH meets USP testing specifications, USP/NF −20°C powder
Click Add to Quote for price and delivery
-
+