Methoctramine hydrate, >=97% (NMR), solid

Methoctramine hydrate, >=97% (NMR), solid

Application

Methoctramine hydrate has been used: As a muscarinic receptor 2 antogonist. As a test molecule to check its effect on premature osteogenic differentiation of HGPS (Hutchinson-Gilford progeria syndrome) iPS (induced pluripotent)-derived mesenchymal stem cells.

Biochem/physiol Actions

Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. In oesophageal muscle, acetylcholine-mediated increase in calcium and arachidonic acid release were reduced by the M2 receptor antagonist, methoctramine. Methoctramine infused bilaterally in the dorsolateral striatum, considerably enhanced memory in cognitively impaired aged rats. Methoctramine plays a vital role in muscarinic receptor classification.

Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. The increase in calcium and arachidonic acid release were attenuated by the M2 receptor antagonist methoctramine, but not by the M3 receptor antagonist p-fluoro-hexahydro siladifenidol.

General description

Methoctramine (N, N?-bis [6-[[(2-methoxyphenyl)-methyl] hexyl]-1, 8-octane] diamine) is a derivative of polymethylene tetramine.

Packaging

10, 25, 100 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3591715 Methoctramine hydrate, >=97% (NMR), solid white 100 XIIINYPADNNZHA-UHFFFAOYSA-N 1S/2C36H62N4O2.4ClH.H2O/c2*1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2;;;;;/h2*1 SIGMA-ALDRICH solid ≥97% (NMR)
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3591716 Methoctramine hydrate, >=97% (NMR), solid white 100 XIIINYPADNNZHA-UHFFFAOYSA-N 1S/2C36H62N4O2.4ClH.H2O/c2*1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2;;;;;/h2*1 SIGMA-ALDRICH solid ≥97% (NMR)
£305.04 (exc VAT) per 10MG
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3591717 Methoctramine hydrate, >=97% (NMR), solid white 100 XIIINYPADNNZHA-UHFFFAOYSA-N 1S/2C36H62N4O2.4ClH.H2O/c2*1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2;;;;;/h2*1 SIGMA-ALDRICH solid ≥97% (NMR)
£598.93 (exc VAT) per 25MG
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