Melittin from honey bee venom, >=85% (HPLC)

Melittin from honey bee venom, >=85% (HPLC)

Amino Acid Sequence

Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2

Application

Melittin from honey bee venom has been used:In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.

Biochem/physiol Actions

Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment.

Binds calmodulin in a Ca2+-dependent manner; inhibits Na+-K+-ATPase.

General description

Chemical structure: peptide

Melittin is hydrophobic in nature except for a region with Lys-Arg-Lys-Arg sequence near C-terminal end. This structural characteristic makes melittin a highly surface-active and a powerful, direct haemolytic agent.† The encoded protein containins 26 amino acids. Monomeric form of melittin has a molecular weight of 2,840 Daltons and tetrameric form has molecular weight of approximately 12,500 Daltons.

Other Notes

The principle hemolytic component of honeybee venom.

Packaging

1, 5, 25 mg in glass bottle

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Code Description InChI key InChI Manufacturer Form Assay Price Quantity
3591748 Melittin from honey bee venom, >=85% (HPLC) VDXZNPDIRNWWCW-JFTDCZMZSA-N 1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-5 SIGMA-ALDRICH lyophilized powder
£89.14 (exc VAT) per 1MG
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3591749 Melittin from honey bee venom, >=85% (HPLC) VDXZNPDIRNWWCW-JFTDCZMZSA-N 1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-5 SIGMA-ALDRICH lyophilized powder
£1,119.86 (exc VAT) per 25MG
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3591750 Melittin from honey bee venom, >=85% (HPLC) VDXZNPDIRNWWCW-JFTDCZMZSA-N 1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-5 SIGMA-ALDRICH lyophilized powder
£316.18 (exc VAT) per 5MG
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