MARINOPYRROLE A

MARINOPYRROLE A

Biochem/physiol Actions

Marinopyrrole A (Maritoclax) is a potent and selective inhibitor of Bcl-2 family member Mcl-1, originally isolated from marine streptomycetes for its antimicrobial activity against methicillin-resistant Staphylococcus aureus. Marinopyrrole A directly binds to Mcl-1 and targets it for proteasomal degradation. Marinopyrrole A induced apoptosis in Mcl-1-dependent cancer cells and sensitized cancer cells to ABT-737.

General description

Marinopyrrole A (Maritoclax) is a member of phenolic 1,3?-bipyrroles family targeting actin group.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575044 MARINOPYRROLE A light yellow to dark yellow 100 SIGMA-ALDRICH −20°C
£532.07 (exc VAT) per 25MG
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3575045 MARINOPYRROLE A light yellow to dark yellow 100 SIGMA-ALDRICH −20°C
£196.39 (exc VAT) per 5MG
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