Manganese(II) chloride solution, for molecular biology, BioReagent

Descriptions

Application

Manganese (II) chloride solution has been used:in manganese enhanced magnetic resonance imaging (MEMRI) to study neuronal disease and manganese toxicityin high ionic strength reaction mixture to determine RNA polymerase I and II activityin reverse transcription reaction mix as a source of Mn₂⁺ ions

General description

Manganese (II) chloride (MnCl₂) might play a key role in integrin activation. Manganese is indispensable for brain function and is an essential cofactor for several key enzymes like superoxide dismutase and enzymes involved in neurotransmitter synthesis. Manganese can modulate iron and calcium homeostasis. Manganese is also used in the magnetic resonance imaging to increase contrast while examining neuronal connections and brain cytoarchitecture. High levels of manganese is toxic to central nervous system and causes Parkinson?s like symptoms called as manganism. MnCl₂ has been used in reverse transcription reaction mix to enhance the template-switching efficiency.

MnCl₂ solution is a source of manganese ions and has a variety of biological uses. In biochemistry, it can be used as a cofactor in restriction enzymes, such as BamH and EcoR V. In molecular biology, Mn₂⁺ can be substituted for Mg₂⁺ as a divalent metal ion to facilitate DNase I activity in presence of Ca₂⁺.

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Code	Description	InChI key	InChI	Manufacturer	Product Line	Form	Price		Quantity
3582004	Manganese(II) chloride solution, for molecular biology, BioReagent	GLFNIEUTAYBVOC-UHFFFAOYSA-L	1S/2ClH.Mn/h2*1H;/q;;+2/p-2	SIGMA-ALDRICH	BioReagent	liquid	£124.88 (exc VAT) per 100ML		- +
3582005	Manganese(II) chloride solution, for molecular biology, BioReagent	GLFNIEUTAYBVOC-UHFFFAOYSA-L	1S/2ClH.Mn/h2*1H;/q;;+2/p-2	SIGMA-ALDRICH	BioReagent	liquid	£62.88 (exc VAT) per 10X1ML		- +