LEUKADHERIN-1

LEUKADHERIN-1

Biochem/physiol Actions

Leukadherin-1 is an agonist of complement receptor-3 (CR3) and exhibits anti-inflammatory activity. It is an allosteric agonist that activates integrin by binding to a different site from the ligand binding. Leukadherin-1 plays an important role in the margination and adhesion of neutrophils to the endothelial lining of the blood vessels.

Leukadherin-1 is an agonist of integrin CD11b/CD18 that can increase the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils. Also, Leukadherin-1 decreases leukocyte recruitment and reduced arterial narrowing after injury in rats.

Packaging

5, 25 mg in glass bottle

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574204 LEUKADHERIN-1 , yellow to orange to brown 100 SIGMA-ALDRICH 2-8°C DMSO: 3 mg/mL, clear (warmed) powder ≥98% (HPLC)
£484.71 (exc VAT) per 25MG
-
+
3574205 LEUKADHERIN-1 , yellow to orange to brown 100 SIGMA-ALDRICH 2-8°C DMSO: 3 mg/mL, clear (warmed) powder ≥98% (HPLC)
£136.78 (exc VAT) per 5MG
-
+