Leflunomide, Immunosuppressant

Leflunomide, Immunosuppressant

Application

By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation and treatment of rheumatoid arthritis and other autoimmune diseases.

Biochem/physiol Actions

Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.

Packaging

25, 100 mg in poly bottle

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Code Description Quality Level mp InChI key InChI Manufacturer Form Assay Price Quantity
3577830 Leflunomide, Immunosuppressant 200 166.5 °C VHOGYURTWQBHIL-UHFFFAOYSA-N 1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18) SIGMA-ALDRICH powder ≥98% (TLC)
£406.71 (exc VAT) per 100MG
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3577831 Leflunomide, Immunosuppressant 200 166.5 °C VHOGYURTWQBHIL-UHFFFAOYSA-N 1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18) SIGMA-ALDRICH powder ≥98% (TLC)
£153.21 (exc VAT) per 25MG
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