LARAZOTIDE ACETATE

LARAZOTIDE ACETATE

Biochem/physiol Actions

Larazotide acetate (AT1001) is a Zonulin receptor antagonist, a tight junction modulator. Larazotide inhibition of zonulin results in reducing trafficking across epithelial cells in the intestines and reducing intestinal permeability and "leaky gut," thought to be a gateway to multiple autoimmune diseases, including celiac disease, irritable bowel syndrome (IBS), inflammatory bowel diseases (IBD, Crohn′s and ulcerative colitis), type 1 diabetes mellitus (T1DM), nonalcoholic steatohepatitis (NASH), chronic kidney disease (CKD) and several others. It has been shown to inhibit the effect of inflammatory cytokines such as tumor necrosis factor (TNF-alpha) and interleukin (IL-4), blocking their increase of intestinal epithelial permeability.

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Code Description Colour Manufacturer Storage Temp. Form Assay Price Quantity
3576370 LARAZOTIDE ACETATE white to beige SIGMA-ALDRICH −20°C powder ≥95% (HPLC)
£501.43 (exc VAT) per 25MG
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3576371 LARAZOTIDE ACETATE white to beige SIGMA-ALDRICH −20°C powder ≥95% (HPLC)
£124.24 (exc VAT) per 5MG
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