Lactoferrin from human milk, >=85% (SDS-PAGE), lyophilized powder

Lactoferrin from human milk, >=85% (SDS-PAGE), lyophilized powder

Application

Lactoferrin was used to grow Streptococcus mutans in an iron-limiting medium. It was used to test if lactoferrin impedes epithelial cell adhesion in vitro.

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Packaging

5 mg in glass bottle

100 mg in glass bottle

25 mg in poly bottle

Preparation Note

Chromatographically purified.

Quality

Contains iron, see certificate of analysis for lot specific information.

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Code Description InChI key InChI Manufacturer Composition Form Assay Price Quantity
3591608 Lactoferrin from human milk, >=85% (SDS-PAGE), lyophilized powder QCBUWCQOKPLTDZ-PKRULZLPSA-N 1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44- SIGMA-ALDRICH Protein, ≥90% biuret lyophilized powder ≥85% (SDS-PAGE)
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3591609 Lactoferrin from human milk, >=85% (SDS-PAGE), lyophilized powder QCBUWCQOKPLTDZ-PKRULZLPSA-N 1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44- SIGMA-ALDRICH Protein, ≥90% biuret lyophilized powder ≥85% (SDS-PAGE)
£391.39 (exc VAT) per 25MG
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3591610 Lactoferrin from human milk, >=85% (SDS-PAGE), lyophilized powder QCBUWCQOKPLTDZ-PKRULZLPSA-N 1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44- SIGMA-ALDRICH Protein, ≥90% biuret lyophilized powder ≥85% (SDS-PAGE)
£156.00 (exc VAT) per 5MG
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